Pharmacokinetic parameters of MDZ in the absence or the presence of ITZ and KTZ
| −ITZ | +ITZ | −KTZ | +KTZ | |
|---|---|---|---|---|
| AUC (μmol · min/ml) | 0.336 ± 0.051 | 0.719 ± 0.155** | 0.291 ± 0.074 | 0.487 ± 0.052** |
| CLtot (ml/min/kg) | 93.3 ± 13.9 | 44.4 ± 9.4** | 111.4 ± 28.5 | 63.9 ± 6.9* |
| T 1/2β (min) | 32.6 ± 0.7 | 65.2 ± 3.0*** | 27.8 ± 3.9 | 33.4 ± 1.0* |
AUC, CLtot, and T1/2β are area under the plasma concentration curve, total body clearance, and half life in β phase, respectively. Values are means ± S.D. (n = 4). Significant differences from −ITZ or −KTZ were determined by Student’s t test (* p< .05, ** p < .01, *** p < .001).