Comparison between predicted value and observed value of increase in ratio of plasma concentration of MDZ
| Inhibitor | Rp 1 + Cpf/Ki | Rh 1 + Chf/Ki | R AUC′/AUC |
|---|---|---|---|
| ITZ | 1.03 ∼ 1.05 | 1.73 ∼ 1.97 | 2.14 |
| KTZ | 1.39 | 1.51 | 1.67 |
| Cimetidine5-a | 1.54 | 2.04 | 2.5 |
| Nizatidine5-a | 1.02 | 1.05 | 1.0 |
The increase ratios, Rp, and RH were calculated from Cpf using eq. 19 and CHf using eq. 17. AUC′/AUC is observed value calculated from Fig. 3.
↵5-a Cited from our report concerning the interaction between histamine H2 receptor antagonists and MDZ (Takedomi et al., 1998).