Table 3

Effect of bile duct cannulation on pharmacokinetics of TAK-603 andM-I in rats after i.v. injection of [14C]TAK-603

CompoundParametersU1 mg/kg15 mg/kg
ControlBile-cannulatedControlBile-cannulated
TAK-603λ1/h1.22  ± 0.031.16  ± 0.140.60  ± 0.100.74  ± 0.083-a
AUC∞ μg · h/ml0.32  ± 0.060.33  ± 0.0413.58  ± 3.3812.70  ± 2.17
M-I T max h0.75  ± 0.290.75  ± 0.291.60  ± 0.551.40  ± 0.55
C max μg/ml0.266  ± 0.0290.296  ± 0.0252.923  ± 0.323.323  ± 0.501
λ1/h0.40  ± 0.050.64  ± 0.153-a 0.29  ± 0.040.47  ± 0.053-b
AUC∞ μg · h/ml0.76  ± 0.170.70  ± 0.1314.11  ± 3.5812.75  ± 3.39

  • Mean value ± S.D. (Dose 15 mg/kg: N = 4, Dose 15 mg/kg: N = 5).

  • ↵3-a Significantly different from the value for control (P < .05).

  • ↵3-b Significantly different from the value for control (P < .01).