Pharmacokinetic parameters of SKP-450 in rats after single oral and i.v. administration of [14C]SKP-450
| Route | Dose | AUCt | Cl | VdSS | T1/2 | Cmax | Tmax |
|---|---|---|---|---|---|---|---|
| mg/kg | ng · h/ml | ml/min/kg | ml/kg | h | ng/ml | h | |
| i.v. | 0.5 | 63 ± 3 | 7880 ± 380 | 1183 ± 198 | 0.05 ± 0.01 | — | — |
| oral | 0.5 | 20 ± 3 | — | — | — | 67 ± 11 | 0.19 ± 0.09 |
| 2.0 | 49 ± 10 | — | — | — | 147 ± 21 | 0.21 ± 0.12 |