Route | Dose | AUCt | Cl | VdSS | T1/2 | Cmax | Tmax | F |
---|---|---|---|---|---|---|---|---|
mg/kg | ng · h/ml | ml/min/kg | ml/kg | h | ng/ml | h | % | |
i.v. | 0.5 | 3011 ± 445 | 250 ± 30 | 357 ± 40 | 1.21 ± 0.21 | — | — | — |
oral | 0.5 | 2930 ± 117 | — | 596 ± 31 | 2.38 ± 0.11 | 801 ± 39 | 0.24 ± 0.04 | 97.3 |
2.0 | 8287 ± 1184 | — | 520 ± 131 | 2.44 ± 0.30 | 2344 ± 492 | 0.18 ± 0.01 | 68.8 |