Table 2

Mean and range of individual pharmacokinetics of H 152/81in male rats (n = 4), female rats (n = 4), and dogs (n = 6, 2 females/4 males) obtained by fitting a two-compartment model to individual concentration of H 152/81versus time data following i.v. bolus administration of metabolite to rats and a one-compartment model following clevidipine infusion in dogs

	V_SS	CL_b	T_1/2λ1	T_1/2λ2	C₁	C₂
	l/kg	l/h/kg	h	h
Male rats
Mean	0.38	0.022	0.4	12.8	0.670	0.330
S.D.	0.05	0.005	0.1	1.5	0.025	0.025
Median	0.39	0.022	0.4	13.3	0.675	0.325
Minimum	0.31	0.017	0.2	10.6	0.642	0.306
Maximum	0.42	0.028	0.5	13.9	0.694	0.358
Female rats
Mean	0.33	0.013^2-150	0.3	18.9^2-150	0.603	0.397
S.D.	0.05	0.002	0.1	3.1	0.038	0.038
Median	0.33	0.013	0.3	19.5	0.605	0.395
Minimum	0.28	0.011	0.2	14.5	0.539	0.373
Maximum	0.38	0.014	0.3	21.9	0.627	0.461

	V	CL_b	T_1/2	C_max	T_max
	l/kg	l/h/kg	h	nmol/l	min
Dogs
Mean	0.96	3.18	0.21	1164	0.59
S.D.	0.32	1.02	0.03	434	0.38
Median	0.86	2.88	0.20	1070	0.43
Minimum	0.65	2.10	0.18	705	0.28
Maximum	1.53	4.62	0.26	1870	1.08

↵2-150 P < .05 for comparison between male and female rats.