Effects of increasing concentrations of taxol and cyclophosphamide on concentrations of metabolites M-IV and M-II in monkey liver microsomal fractions
| Drug and Concentration | Concentration | ||
|---|---|---|---|
| M-IV | M-II | ||
| μM | |||
| Control | 2.36 ± 0.11 | 7.39 ± 0.08 | |
| Taxol | |||
| 1 μM | 2.71 ± 0.13 | 6.93 ± 0.11 | p = 0.07 |
| 5 μM | 4.34 ± 0.20 | 5.01 ± 0.14 | p < 0.001 |
| Cyclophosphamide | |||
| 10 μM | 2.80 ± 0.05 | 6.80 ± 0.01 | p < 0.05 |
| 25 μM | 3.41 ± 0.02 | 6.48 ± 0.02 | p < 0.01 |
| 50 μM | 4.11 ± 0.37 | 5.45 ± 0.21 | p < 0.01 |
Each value of M-IV and M-II represents mean ± S.E. of three independent experiments with duplicate incubation.
p value represents statistical significance of differences in M-IV and M-II concentrations in absence (control) or presence of taxol or cyclophosphamide.