Parameter | Animal Group | |
---|---|---|
PGP (+/+) | PGP (−/−) | |
AUC(0–24) (ng · h/ml) | 1783.3 | 1984.7 |
Cl (ml/min/kg) | 9.3 | 8.4 |
Vdss (l/kg) | 2.1 | 2.3 |
T 1/2 (h) | 3.99 | 3.32 |
MRT (h) | 3.68 | 4.49 |
Blood AUC (0–24 h) was calculated by the linear trapezoidal rule using concentrations (n = 3) at each time point after i.v. administration.