Table 4

Degradation of the d-MPH, d-OCH3 MPH, and d-Br MPH in phosphate buffer and rat plasma

CompoundHalf-life4-a4-b
Phosphate bufferRat plasma
h
MPH8.711.98
p-OCH3MPH7.376.05
p-Br MPH5.9116.6

  • ↵4-a An average of three samples for each time point was used to generate the half-life values.

  • ↵4-b Half-lives were calculated using WinNonlin.