Mean (±S.D.) pharmacokinetic parameters of DA-1131 after 1-min i.v. infusion of the drug, 50 mg/kg, to 16-week-old SHRs and their age-matched control KW rats
| Parameters | KW Rats 1-a (n= 12) | SHRs 1-a (n = 7) |
|---|---|---|
| Terminal half-life (min) | 25.2 ± 3.76 | 15.7 ± 1.54*** |
| AUC (μg · min/ml) | 7070 ± 862 | 4720 ± 785*** |
| MRT (min) | 20.1 ± 2.04 | 14.4 ± 1.13*** |
| CL (ml/min/kg) | 7.07 ± 0.871 | 10.6 ± 1.98*** |
| CLR(ml/min/kg) | 3.41 ± 0.615 | 4.69 ± 1.79* |
| CLNR(ml/min/kg) | 3.57 ± 0.594 | 5.37 ± 1.26*** |
| V SS (ml/kg) | 141 ± 19.6 | 152 ± 31.3 |
| Ae 0–8 h (% of i.v. dose) | 48.9 ± 5.77 | 48.0 ± 11.3 |
| Creatinine clearance (ml/min/kg) | 3.98 ± 0.776 | 3.15 ± 0.756* |
| Liver (% of body weight) | 3.14 ± 0.164 | 3.12 ± 0.209 |
| Kidney (% of body weight) | 0.718 ± 0.0379 | 0.758 ± 0.0147* |
↵1-a P values are as follows: * p < .05; ** p < .01; *** p < .001.