Mean (±S.D.) pharmacokinetic parameters of DA-1131 after 1-min i.v. infusion of the drug, 50 mg/kg, to 6-week-old SHRs and their age-matched control KW rats
| Parameters | KW Rats 2-a (n= 10) | SHRs 2-a (n = 7) |
|---|---|---|
| Terminal half-life (min) | 16.3 ± 1.59 | 15.5 ± 2.24 |
| AUC (μg · min/ml) | 4680 ± 577 | 3800 ± 493** |
| MRT (min) | 13.5 ± 1.84 | 11.6 ± 1.89 |
| CL (ml/min/kg) | 10.7 ± 1.38 | 13.2 ± 1.92** |
| CLR(ml/min/kg) | 6.44 ± 1.46 | 4.97 ± 1.74 |
| CLNR(ml/min/kg) | 3.31 ± 1.86 | 7.73 ± 1.51*** |
| V SS (ml/kg) | 141 ± 31.4 | 149 ± 28.6 |
| Ae 0–8 h (% of intravenous dose) | 63.0 ± 13.8 | 40.4 ± 9.78** |
| Creatinine clearance (ml/min/kg) | 2.87 ± 0.778 | 3.11 ± 0.684 |
| Liver (% of body weight) | 4.12 ± 0.343 | 4.64 ± 0.675 |
| Kidney (% of body weight) | 0.901 ± 0.0484 | 0.964 ± 0.0933 |
↵2-a P values are as follows: ** p < .01; *** p < .001.