Table 4

Mean (±S.D.) amount (μg) of DA-1131 remaining per gram of tissues after 30-min incubation of 50 μg of DA-1131 with 9000g supernatant fraction of kidney and liver homogenates in SHRs (n = 3) and KW rats (n = 3) of 6 weeks of age, and SHRs (n = 5), KW rats (n = 3), DOCA-salt-induced hypertensive rats (n = 3), and Sprague-Dawley rats (n = 3) of 16 weeks of age

Tissues6 Weeks of Age 4-a 16 Weeks of Age 4-a 16 Weeks of Age 4-a
KW ratsSHRsKW ratsSHRsSprague-Dawley ratsDOCA-Salt rats
Kidney7.19  ± 1.720.729  ± 0.0970** 1.49  ± 0.775UD 4-b UD 4-b 0.690  ± 0.105
Liver1.99  ± 1.2419.2  ± 2.86*** 22.7  ± 3.7611.7  ± 3.29* 2.15  ± 1.057.26  ± 2.81*
  • 4-a P values are as follows: * p < .05; ** p < .01; *** p < .001.

  • 4-b Under detection limit (the detection limit of DA-1131 in tissue homogenate was 0.1 μg/g kidney).