NDPS and DFPS tissue concentrations
| Tissue | Concentration 3-a | |
|---|---|---|
| 14C-NDPS | 14C-DFPS | |
| nmol/g tissue | ||
| Kidney | 198.8 ± 45.2 | 38.4 ± 3.9 3-b |
| Liver | 59.4 ± 15.8 3-c | 20.7 ± 3.3 |
| Heart | 35.1 ± 15.1 3-c | 5.9 ± 1.9 |
Male Fischer 344 rats were administered 14C-NDPS or14C-DFPS (approximately 10 μCi; 0.2 mmol/kg i.p. in corn oil). Samples were taken at 6 h for NDPS and 3 h for DFPS. Radiolabel content was determined by liquid scintillation counting.
↵3-a Values are means ± S.E. of N = 4 rats.
↵3-b Values that are significantly different (p < .05) from the corresponding NDPS value in the same tissue.
↵3-c Values that are significantly different (p < .05) from the corresponding values in the kidney for the same compound.