Table 1

Pharmacokinetic parameters of VPA in normal rats, nephrectomized rats, and hepatectomized rats, with or without PAPM treatment

	Normal S.D.		Nephrectomized		Hepatectomized
	VPA alone	PAPM treatment	VPA alone	PAPM treatment	VPA alone	PAPM treatment
CL_tot(ml/h/kg)	343.3 ± 62.0 ^1-a	605.2 ± 47.4^1-150	258.8 ± 43.9	423.5 ± 58.7^1-150	125.5 ± 39.5	97.6 ± 24.3
T _1/2 (h)	0.44 ± 0.09	0.18 ± 0.01^1-150	0.58 ± 0.07	0.27 ± 0.06^1-150	1.56 ± 0.46	2.16 ± 0.70
V _d(ml/kg)	211.6 ± 13.2	161.6 ± 17.4^1-150	218.5 ± 51.4	165.5 ± 50.2	265.9 ± 25.3	289.2 ± 39.0
n^1-b	6	4	3	3	3	3

↵1-a Values are the mean ± S.D.
↵1-b n, number of determinations.
↵1-150 P < .01 by Student’s t-test.