Table 2

Proportion and cumulative recovery of each metabolite in bile after intravenous administration of 14C-VPA at 30 mg/kg, with or without PAPM treatment

Proportion of each metabolite in bile 2-a Cumulative recovery
VPA alonePAPM treatmentVPA alonePAPM treatment
TLC % % of Dose
VPA2.7  ± 1.2 2-b 1.6  ± 1.01.1  ± 0.50.9  ± 0.6
BM-2 3.9  ± 0.64.2  ± 2.61.7  ± 0.32.4  ± 1.5
VPA glucuronide89.4  ± 1.590.6  ± 4.738.3  ± 0.752.5  ± 2.7
BM-1 2.9  ± 0.82.6  ± 0.61.3  ± 0.41.5  ± 0.4
n2-c 3535
  • 2-a The batches of bile collected (90–120 min) were assayed.

  • 2-b Values are the mean ± S.D.

  • 2-c n, number of determinations.