PAPM added | VPA deconjugated from VPA-Glu |
---|---|
μg/ml | μmol/h/g liver |
0 | 3.593 ± 0.119 5-a |
50 | 3.573 ± 0.239 |
500 | 3.793 ± 0.047 |
Bile collected after intravenous administration of VPA to rats was used as the substrate. VPA-Glu in the bile was finally at 0.416 mM and incubated for 60 min with 25% liver homogenate used as β-glucuronidase.
↵5-a Values are the mean ± S.D., n = 3.