Time relationships of appearance of each drug in forming hair and sebaceous glands
| Drug | Time Postdose | Number of Silver Grains per 625 μm2 | Percentage of Positive Sebaceous Glands | ||
|---|---|---|---|---|---|
| C57 | Balb/C | C57 | Balb/C | ||
| Flunitrazepam | 10 min | 29.9 ± 2.51 2-a 2-b 2-c | 8 ± 1.65 | 1.5 | 99 2-a 2-b |
| 1 h | 110 ± 9.67 2-a 2-b 2-c | 6 ± 2.10 | 0 | 60 2-a 2-b | |
| 5 h | 441 ± 14.6 2-a 2-b 2-c | 10 ± 1.54 | 0 | 60 2-a 2-b | |
| Cocaine | 5 min | 13.1 ± 2.46 2-a 2-b 2-c | 5 ± 1.42 | 1.3 | 0 |
| 15 min | 17.9 ± 1.81 2-a 2-b 2-c | 6 ± 1.23 | 43 2-a | 30 2-a | |
| 1 h | 26.5 ± 5.19 2-a 2-b 2-c | 8 ± 2.32 | 40 2-a | 29 2-a | |
| Nicotine | 5 min | 40.1 ± 6.48 2-a 2-b 2-c | 9 ± 1.02 | 4.2 | 0 |
| 15 min | 90.6 ± 14.2 2-a 2-b 2-c | 6 ± 1.44 | 0 | 1.9 | |
| 1 h | 195 ± 36.5 2-a 2-b 2-c | 7 ± 2.11 | 0 | 0 | |
Silver grain counts are mean of 10 follicles ± 1 S.D. from two individuals. Percentage of positive sebaceous glands were figured from counts of 200 sebaceous glands. Positive glands had more than 100 silver grains present per gland. Background silver grain counts were five grains per 625 μm2 field.
↵2-a Significantly different from control animals by one-way ANOVA with significance assumed at p < .01.
↵2-b Significantly different from other strain by one-way ANOVA with significance assumed at p < .01.
↵2-c Silver counts for each time point were significantly greater than previous time point by ANOVA with significance assumed atp < .01.