Zeroth, first, and second moments of parent drug that is metabolized by enzymes that are heterogeneously distributed in liver (k30 = 0)
| Data Sets | A | B | C | |
|---|---|---|---|---|
| Transfer coefficients 2-a | k 13 | 4.00 | 4.00 | 0.25 |
| k 31 | 4.00 | 0.25 | 0.25 | |
| k 34 | 4.00 | 0.25 | 0.25 | |
| k 13/k 31 | 1.0 | 16.0 | 1.0 | |
| AUC × Q | pp | 0.264 | 0.264 | 0.920 |
| even | 0.135 | 0.135 | 0.882 | |
| pv | 0.264 | 0.264 | 0.920 | |
| MTT 2-b | pp | 1.56 | 9.89 | 1.56 |
| even | 1.25 | 5.00 | 1.25 | |
| pv | 1.56 | 9.89 | 1.56 | |
| CV2 | pp | 0.107 | 0.679 | 1.714 |
| even | 0.040 | 0.640 | 0.640 | |
| pv | 0.107 | 0.679 | 1.714 |
even: homogeneous acinar enzyme distribution. AUC × Q is recovery.
↵2-a Transfer coefficients were normalized by multiplying by the transit time of the whole sinusoid.
↵2-b MTTs were normalized by dividing by the transit time of the whole sinusoid.
2-c Variances were normalized by dividing by the square of the transit time of the whole sinusoid.