Human Liver Microsomes | Formation ofLMA7 from Rokitamycin | Formation of LMV from LMA7 | ||||
---|---|---|---|---|---|---|
Km | Vmax | Vmax/Km | Km | Vmax | Vmax/Km | |
μM | nmol/mg/min | ml/mg/min | μM | nmol/mg/min | ml/mg/min | |
HL-31 | 5.23 | 18.28 | 3.50 | 37.8 | 3.33 | 0.088 |
HL-32 | 7.01 | 28.60 | 4.08 | 39.4 | 4.87 | 0.124 |
HL-33 | 4.86 | 31.82 | 6.55 | 37.8 | 5.53 | 0.146 |
HL-34 | 5.33 | 32.29 | 6.06 | 29.5 | 7.24 | 0.245 |
HL-39 | 3.93 | 22.97 | 5.84 | 36.5 | 6.66 | 0.182 |
HL-40 | 2.65 | 12.21 | 4.61 | 32.0 | 2.5 | 0.078 |
Mean | 4.841-160 | 24.361-160 | 5.111-160 | 35.5 | 5.02 | 0.144 |
± S.D. | 1.46 | 8.04 | 1.22 | 3.87 | 1.85 | 0.063 |
↵1-160 P < .01 compared with the respective mean data obtained from the formation of LMV fromLMA7.