Table 1

Effect of GF120918 pretreatment on the systemic disposition of morphine and M3G

Parameter1-aControlGF120918
AUCu(μM · min)22.7  ± 4.832.3  ± 4.2
CLu (ml/min/kg)160  ± 36110  ± 15
V SS (l/kg)10.8  ± 2.611.4  ± 3.4
T 1/2 (min)1-b 42.2  ± 0.861.1  ± 13.0
MRT (min)67.6  ± 2.2104  ± 31.7
M3G AUCu (μM · min)14.7  ± 5.737.1  ± 5.61-150
M3G T 1/2 (min)1-b 42.1  ± 4.489.6  ± 24.61-150

  • ↵1-a Mean ± S.D.; n = 3 per treatment.

  • ↵1-b Harmonic mean ± jackknife S.D.

  • ↵1-150  p < .05 (unpaired t test).