Table 2

Effect of GF120918 pretreatment on the CNS disposition of morphine and M3G

Parameter2-aControlGF120918
AUCu(μM · min)10.8  ± 3.339.7  ± 14.32-150
T 1/2 (min)2-b 69.6  ± 4.1194.6  ± 64.22-150
Brain:blood AUC ratio0.47  ± 0.051.21  ± 0.342-150
M3G AUCu(μM · min)9.7  ± 1.716.8  ± 4.82-150
M3GT 1/2 (min)2-b 118  ± 40173  ± 39
M3G brain:blood AUC ratio0.68  ± 0.470.45  ± 0.06

  • ↵2-a Mean ± S.D.; n = 3 per treatment.

  • ↵2-b Harmonic mean ± jacknife S.D.

  • ↵2-150  p < .05 (unpaired t test).