Table 2

Kinetics of the metabolism of ABT-378 by human liver microsomes and CYP3A4 lymphoblastoid microsomes

Subject IDAgeSexRaceKmVmaxCLint
years μM nmol/mg protein/min ml/mg/min
IE442046FemaleCaucasian10.113.91.37
IEN01666MaleCaucasian1.62.21.34
IAY14851FemaleCaucasian7.713.61.76
IEG71054FemaleCaucasian7.77.91.01
Mean 6̅.̅8̅ ̅±̅ ̅3̅.̅6̅ 9̅.̅4̅ ̅±̅ ̅5̅.̅5̅ 1̅.̅3̅7̅ ̅±̅ ̅0̅.̅3̅1̅
Pooled2-a 7.017.42.47
CYP3A41.629.32-b 17.952-c

  • ↵2-a Equal mg quantities of microsomes from all four livers were pooled.

  • ↵2-b Value is nmol/nmol CYP/min.

  • ↵2-c Value is ml/nmol CYP/min.