Substrate | Isoform | Expression System | Incubation Time | Protein Concentration |
---|---|---|---|---|
min | mg/ml (pmol CYP/ml) | |||
E. coli membranes | 15 | 0.1 (22) | ||
Ethoxyresorufin | CYP1A2 | B-lymphoblasts | 15 | 0.1 (14) |
HLM | 15 | 0.1 | ||
E. colimembranes | 15 | 0.2 (77) | ||
Naproxen | CYP2C9 | B-lymphoblasts | 5 | 1.4 (67) |
HLM | 5 | 1 | ||
E. colimembranes1-a | 15 | 0.7 (40) | ||
Baculosomes | 15 | 0.4 (40) | ||
Diazepam | CYP2C19 | B-lymphoblasts | 15 | 0.2 (50) |
HLM | 20 | 0.25 | ||
E. colimembranes | 15 | 0.06 (32) | ||
Dextromethorphan | CYP2D6 | B-lymphoblasts | 15 | 0.24 (8.4) |
HLM | 15 | 0.85 | ||
E. colimembranes | 10 | 0.05 (25) | ||
Erythromycin | CYP3A4 | B-lymphoblasts | 10 | 0.1 (5) |
HLM | 15 | 0.5 |
↵1-a Represents the one plasmid CYP2C19 expression construct.