Table 6

Major radioactive components (percentage of dose) in female dog bile after administration of 4- to 8-h bile sample (10 μCi) collected after a single 10 mg/kg dose of [¹⁴C]AT

Interval (h)	Approximate Retention Time and Component Number
Interval (h)	8 (1)	12^6-a (2)	40^6-b (3)	68^6-c(4)	70^6-d (6)	87^6-e (7)	89^6-f(8)
0–2	ND	0.12	0.37	0.63	0.95	ND	ND
2–4	ND	0.28	2.05	0.73	0.83	ND	ND
4–8	ND	0.23	1.56	0.49	0.46	ND	ND
Total		0.63	3.98	1.85	2.23	ND	ND	8.69

ND, not determined. Retention times given in minutes. Values in parentheses are component numbers.
↵6-a Glucuronide of ortho-hydroxy AT.
↵6-b para-hydroxy AT.
↵6-c ortho-hydroxy AT.
↵6-d AT.
↵6-e β-Oxidized hydroxy AT.
↵6-f β-Oxidized AT.