Total MON metabolism (% of metabolized substrate/mg protein × 30 min) in liver microsomes from rats untreated or pretreated with PB, PCN, or DEX
| Source of Microsomes | Extent of MON Metabolism (%) |
|---|---|
| UT | 4.4 ± 0.6 |
| PB | 11.4 ± 0.2 |
| PCN | 20.8 ± 0.2 |
| DEX | 42.9 ± 1.3 |
Microsomes, buffer containing an NADPH · generating system, and 0.25 mM MON were incubated for 30 min; reactions were stopped with methanol, and the amount of MON was determined by HPLC as described inMaterials and Methods.
Values are means ± S.E. of four to six incubations.