Table 1

Effect of nicotine diet on lung, kidney, and liver microsomal EROD and MROD activities

Dietary Nicotine	EROD		MROD
Dietary Nicotine	Lung	Kidney	Liver	Lung	Kidney	Liver
mg/kg diet	pmol resorufin formed/mg protein/min
0	8.3 ± 1.8	9.3 ± 4.4	218.4 ± 63.3	10.4 ± 4.8	8.3 ± 1.8	97.8 ± 56.2
	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)	(1.0)
20	15.6 ± 6.2	13.3 ± 7.4	369.6 ± 89.7	21.8 ± 3.2^a	15.6 ± 5.4	160.2 ± 61.6
	(1.9)	(1.4)	(1.7)	(2.1)	(1.9)	(1.6)
60	40.5 ± 8.2^a	15.6 ± 6.2	633.7 ± 116.8^a	33.3 ± 3.6^b	19.8 ± 7.2^a	351.5 ± 93.7^a
	(4.9)	(1.7)	(2.9)	(3.2)	(2.4)	(3.6)
200	178.9 ± 39.5^b	147.7 ± 39.3^a	1117.0 ± 200.0^b	45.8 ± 1.8^c	71.8 ± 33.0^b	848.6 ± 205.0^b
	(21.6)	(15.9)	(5.1)	(4.4)	(8.7)	(8.7)

Each value is the mean (±S.D.) of determinations in four to six animals. Each value in parentheses is the fold-increase over the control (zero-nicotine dietary group) of the same column. a, b, and c: Values bearing different superscripts within the same column are significantly different from each other, from values bearing no superscripts, and from the control (p < .05).