Subject | Metabolites (% of Dose Administered) | |||||||
---|---|---|---|---|---|---|---|---|
Midnight–8:00 AM urine collection after 750 mg SCMC2-a | ||||||||
SCMC | SCMCSO | SMC | SMCSO | TDA | TDASO | CMTC | %SO | |
1 | 17.2 | 2.0 | 1.1 | N.D. | 8.4 | N.D. | N.D. | 2.0 |
2 | 33.4 | 4.1 | 3.2 | N.D. | 11.5 | N.D. | N.D. | 4.1 |
3 | 8.3 | 3.2 | N.D. | 1.0 | 15.7 | N.D. | N.D. | 4.2 |
4 | 5.1 | N.D. | 2.0 | N.D. | 20.2 | N.D. | N.D. | 0.0 |
5 | 15.3 | 3.0 | 1.0 | N.D. | 23.4 | N.D. | N.D. | 3.0 |
8:00 AM–4:00 PM urine collection after 750 mg SCMC2-b | |||||||||
---|---|---|---|---|---|---|---|---|---|
SCMC | SCMCSO | SMC | SMCSO | TDA | TDASO | CMTC | %SO | SCMC/CMTC | |
1 | 5.2 | 1.0 | N.D. | N.D. | 10.2 | 20.5 | 3.1 | 21.5 | 1.67 |
2 | 4.0 | N.D. | N.D. | N.D. | 12.3 | 15.4 | 1.0 | 15.4 | 4.00 |
3 | 12.1 | 2.1 | N.D. | N.D. | 5.7 | 19.4 | 5.2 | 21.5 | 2.32 |
4 | 10.5 | 2.0 | 1.0 | N.D. | 14.1 | 18.6 | 3.4 | 20.6 | 3.08 |
5 | 6.1 | 1.1 | N.D. | N.D. | 9.5 | 23.7 | 3.1 | 24.8 | 1.96 |
Midnight–4:00 PM urine collection after 750 mg SCMC2-c | ||||||||||
---|---|---|---|---|---|---|---|---|---|---|
SCMC | SCMCSO | SMC | SMCSO | TDA | TDASO | CMTC | %Total | %SO | SCMC/CMTC | |
1 | 22.4 | 3.0 | 1.1 | N.D. | 18.6 | 20.5 | 3.1 | 68.7 | 23.5 | 7.22 |
2 | 37.4 | 4.1 | 3.2 | N.D. | 23.8 | 15.4 | 1.0 | 84.9 | 19.5 | 37.4 |
3 | 20.4 | 5.3 | N.D. | 1.0 | 21.4 | 19.4 | 5.2 | 72.7 | 25.7 | 3.9 |
4 | 15.6 | 2.0 | 3.0 | N.D. | 34.3 | 18.6 | 3.4 | 76.9 | 20.6 | 4.58 |
5 | 21.4 | 4.1 | 1.0 | N.D. | 32.9 | 23.7 | 3.1 | 86.2 | 27.8 | 6.90 |
Mean ± S.D. | 23.4 ± 7.3 | 3.7 ± 1.1 | 2.1 ± 1.0 | 26.2 ± 6.2 | 19.5 ± 2.6 | 3.2 ± 1.3 | 77.9 ± 6.7 | 23.4 ± 3.0 | 12.0 ± 12.7 | |
Range | 15.6–37.4 | 2.0–5.3 | 1.0–3.2 | 8.6–34.3 | 15.4–23.7 | 1.0–5.2 | 68.7–86.2 | 19.5–27.8 | 3.9–37.4 |
%Total, % total drug-related compounds recovered in urine collection; %SO, % S-oxides recovered in urine collection; N.D., not detected.
↵2-a Analysis of midnight to 8:00 AM urine collection after administration of 750 mg SCMC to five volunteers at midnight.
↵2-b Analysis of 8:00 AM to 4:00 PM urine collection after administration of 750 mg SCMC to five volunteers at midnight.
↵2-c Analysis of midnight to 4:00 PM urine collection after administration of 750 mg SCMC to five volunteers at midnight.