Table 1

Michaelis-Menten constant (K_m), maximum velocity (V_max), inhibition constant for diclofenac (K_i), and intrinsic clearance (Cl_i) of codeine-6-glucuronide formation in homogenates of liver and small intestinal enterocytes

Homogenate	K_m	S.E.	V_max	S.E.	K_i	χ²	Cl_i
	μM		pmol/min/mg		μM		μl/min/mg
Liver donor no. 1	1547	55.8	89.0	1.23	9.1	1.91	0.058
Liver donor no. 2	1707	64.6	131	1.86			0.077
Liver donor no. 3	1211	40.8	60.8	0.68	6.8	2.12	0.050
Small intestine donor no. 2	2149	311	11.1	0.51			0.005
Small intestine donor no. 3	1565	219	5.80	0.28			0.004

Mean K_m and V_max of codeine-6-glucuronidation in liver homogenate: 1488 μM, 93.6 pmol/min/mg; mean K_m andV_max of codeine-6-glucuronidation in enterocyte homogenate (small intestine): 1857 μM, 8.5 pmol/min/mg; meanK_i of diclofenac on codeine-6-glucuronidation in liver homogenate: 7.9 μM.