Concentrations of Oxo and 5-FU in selected tissues of rats (n = 3) at 1 and 6 h after p.o. administration of S-1 containing [14C]Oxo at a dosage of 5 mg/kg
| Tissue | Time after Administration | Oxo | 5-FU |
|---|---|---|---|
| h | nmol eq/ml or g | nmol/ml or g | |
| Plasma | 1 | 0.12 ± 0.05 | 1.03 ± 0.27 |
| 6 | 0.01 ± 0.00 | 0.30 ± 0.14 | |
| Stomach | 1 | 14.73 ± 8.47 | —1-a |
| 6 | 2.83 ± 0.91 | — | |
| Small intestine | 1 | 23.06 ± 1.78 | 0.85 ± 0.23 |
| 6 | 2.69 ± 1.03 | 1.08 ± 0.14 | |
| Cecum | 1 | 0.21 ± 0.05 | — |
| 6 | 5.89 ± 1.09 | — | |
| Large intestine | 1 | 0.09 ± 0.02 | — |
| 6 | 4.35 ± 2.02 | — | |
| Liver | 1 | 0.04 ± 0.01 | — |
| 6 | ND1-b | — | |
| Kidney | 1 | 0.16 ± 0.03 | — |
| 6 | 0.03 ± 0.00 | — | |
| Spleen | 1 | ND | — |
| 6 | ND | — | |
| Lung | 1 | ND | — |
| 6 | ND | — | |
| Bone marrow | 1 | ND | — |
| 6 | ND | — | |
| Tumor | 1 | ND | 1.40 ± 0.40 |
| 6 | ND | 3.35 ± 1.13 |