Table 4

Degradation of [14C]Oxo after a 1-h incubation in gastric juice, cecum content homogenate, small intestinal S9, hepatic S9, neutralized gastric juice, or sterilized cecal content homogenate

MaterialOxo4-a5-AZU4-bCA4-bOthers4-b
%
Gastric juice (pH 1.6)27.6  ± 1.868.4  ± 2.0ND4-c 4.0  ± 0.3
Cecum content homogenate33.4  ± 1.6ND58.9  ± 2.87.7  ± 1.9
Small intestinal S989.6  ± 3.0ND5.4  ± 2.04.9  ± 1.1
Hepatic S96.3  ± 1.20.8  ± 0.74.0  ± 0.990.6  ± 0.8
Neutralized gastric juice (pH 7.0)97.7  ± 0.60.2  ± 0.3ND2.1  ± 0.8
Sterilized cecum content homogenate87.3  ± 1.3ND5.2  ± 0.27.5  ± 1.1

Each value represents the means ± S.D. (n = 3).

  • ↵4-a  Percentage of Oxo after incubation.

  • ↵4-b  Percentage generated after incubation.

  • ↵4-c  ND, not detected.