Physiological parameters and propranolol pharmacokinetics in isolated perfused livers of sham and RVF rats
| Sham (n = 8) | RVF (n = 5) | |
|---|---|---|
| Body weight (g) | 464 ± 61 | 466 ± 30 |
| Right ventricle weight (g) | 0.76 ± 0.14 | 1.19 ± 0.121-160 |
| Liver weight (g) | 12.1 ± 2.2 | 12.8 ± 2.4 |
| Lung weight (g) | 2.02 ± 0.47 | 2.23 ± 0.53 |
| Central venous pressure (mm Hg) | 1 ± 1 | 10 ± 21-160 |
| Perfusion flow rate (ml/min/g of liver) | 1.52 ± 0.28 | 1.55 ± 0.22 |
| O2delivery (μmol/min/g of liver) | 5.72 ± 1.05 | 5.87 ± 0.85 |
| O2 consumption (μmol/min/g of liver) | 4.66 ± 0.50 | 4.18 ± 0.70 |
| Perfusion pressure (cm H2O) | 9 ± 2 | 11 ± 2 |
| Perfusate pH | 7.31 ± 0.07 | 7.30 ± 0.07 |
| Bile flow (ml/h) | 1.28 ± 0.36 | 1.33 ± 0.01 |
| Propranolol extraction ratio | 0.991 ± 0.006 | 0.688 ± 0.1221-160 |
| Propranolol clearance (ml/min/g of liver) | 1.52 ± 0.25 | 1.07 ± 0.211-150 |