Table 1

The kinetics of bupropion hydroxylation in microsomes from four human livers and cDNA-expressed CYP2B6

Liver Sample	V_max^1-a	K_m^1-b	V_max/K_m^1-c
HLM1	7675	127	60
HLM2	477	72	7
HLM3	2468	67	37
HLM4	3874	91	43
Mean^1-d	3623	89	37
S.E.^1-e	1520	14	11
CYP2B6	7.4^1-f	85	86.3^1-g

↵1-a V_max in units of picomoles per minute per milligram of protein.
↵1-b K_m in units of micromolar.
↵1-c V_max/K_m = intrinsic clearance, in units of microliters per minute per milligram of protein.
↵1-d Mean = arithmetic mean of HLM1–4.
↵1-e S.E. = standard error of HLM1–4.
↵1-f V_max in units of picomoles per minute per picomole of CYP.
↵1-g V_max/K_m = intrinsic clearance, in units of nanoliters per minute per milligram of protein.