Table 2

IC₅₀ values for inhibition of CYP2D6 by bupropion and hydroxybupropion in four different human livers

Liver Sample	IC₅₀^2-a Value
Liver Sample	Bupropion	Hydroxybupropion
HLM1	50	65
HLM2	80	94
HLM3	51	63
HLM4	52	72
Mean	58	74
S.E.	7	7

[Dextromethorphan] = 25 μM.

↵2-a IC₅₀ in units of micromolar.