Excretion of radioactivity in urine, bile, and feces from rats and dogs after administration of [14C]rofecoxib at 2 mg/kg (i.v.) or 5 mg/kg (p.o.)
| Time (h) | Percentage of Dose Excreted1-a | ||||
|---|---|---|---|---|---|
| Rat | Dog | ||||
| 2 mg/kg, i.v. | 5 mg/kg, p.o. | 2 mg/kg, i.v. | 5 mg/kg, p.o. | ||
| Urine | 0–24 | 19.2 (1.7) | 20.1 (1.1) | 47.8 (4.6) | 11.4 (1.2) |
| 0–96 | 23.1 (1.9) | 25.6 (2.0) | 49.2 (5.2) | 17.5 (1.4) | |
| Feces | 0–24 | 61.3 (4.3) | 51.9 (13.6) | 27.7 (2.9) | 70.5 (3.7) |
| 0–96 | 74.5 (2.3) | 72.3 (7.0) | 34.8 (2.6) | 76.0 (3.1) | |
| Total | 0–96 | 97.6 (2.6) | 97.9 (6.9) | 84.0 (7.0) | 93.5 (2.7) |
| Bile1-b | 0–24 | 59.4 (30.6) | 68.7 (9.9) | 28.2 | 26.5 |