Table 1

Kinetic parameters of amiodarone N-deethylase activity in human liver microsomes

HLGKMVmax
μM pmol/min/pmol CYP
119.41.0
426.41.3
632.61.0
738.60.9
1038.22.6
1134.60.6
Mean ± S.D.31.6 ± 7.51.2 ± 0.7