Table 1

Mean CFX pharmacokinetic parameters following per os or i.a. administration of 22.4 mg/kg

GroupCFX AdministrationNFP or PlaceboNFP or Placebo AdministrationFrequency of NFP or PlaceboMean (S.D.) for Pharmacokinetic Parameter
nAUCt1/2Tmax
mg · min/l min min
1per osPlaceboi.a.Acute91389 (340)96 (12)40 (15)
2NFPi.a.Acute91779 (364)1-a 92 (37)47 (16)
3Placeboper osAcute91323 (317)92 (24)50 (15)
4NFPper osAcute101771 (292)1-b 77 (19)47 (16)
7NFPper osChronic61660 (340)1-b 76 (17)50 (15)
5i.a.Placeboper osAcute61614 (377)48 (6)
6NFPper osAcute71747 (379)45 (5)
8NFPper osChronic71723 (203)63 (8)1-c

CFX administration was preceded by either acute or chronic administration of 10 mg/kg nifedipine or placebo.

  • ↵1-a  P < .05 versus placebo i.a.

  • ↵1-b  P < .05 versus placebo per os.

  • ↵1-c  P < .05 versus i.a. placebo per os group.