CLint of marker substrates in different HLM pools and literature values
| Compound | CLint | References | ||||
|---|---|---|---|---|---|---|
| Batch 1 | Batch 2 | Batch 3 | Mean | Literature | ||
| μl · min−1mg−1 | ||||||
| Tolbutamide | 0.73-a | 0.5–2.5; 1 ± 0.2 | Iwatsubo et al. (1997),Doecke et al. (1991), Back et al. (1988), Bourrie et al. (1996), Obach (1999) | |||
| Diazepam | 3 ± 1 | 2 | 2 | 3 ± 1 | 2.6 ± 0.8 | Obach (1999) |
| Metoprolol | 7 ± 1 | 5 | 5 | 6 ± 1 | 14, 19 | Mautz et al. (1995) |
| Ibuprofen | 14 | 5 | 5 | 8 ± 2 | 9.6 ± 1.1 | Obach (1999) |
| Propranolol | 16 ± 3 | 16 | 15 | 15 ± 0 | 11–60 | Lave et al. (1997), Obach (1997), Otton et al. (1990) |
| Dextromethorphan | 29 ± 3 | 30 | 33 | 29 ± 3 | 25–103 | Kerry et al. (1994), Broly et al. (1990) |
| Omeprazole | 43 ± 7 | 11 | 15 | 34 ± 14 | 18, 26 | Andersson et al. (1993),Kobayashi et al. (1994) |
| Diltiazem | 56 ± 7 | 22 | 22 | 45 ± 16 | 17 ± 2 | Obach (1999) |
| Testosterone | 81 ± 12 | 23 | 35 | 60 ± 18 | ||
| Verapamil | 380 ± 44 | 111 | 114 | 256 ± 100 | 139 ± 3 | Obach (1999) |
↵3-a Determined fromVmax/Km. Where determined, results are presented as mean ± S.D.