Table 6

Determination of CYP Cl_int for marker and AR-C compounds

Compound	CL_int
Compound	HLM	CYP
	μl · min⁻¹mg⁻¹
Tolbutamide	0.7^6-a	1.3^6-a
Diazepam	3 ± 1	2 ± 1
Metoprolol	6 ± 1	7 ± 0
Ibuprofen	8 ± 2	20 ± 5
Propranolol	15 ± 0	55 ± 15
Dextromethorphan	29 ± 3	14 ± 1
Omeprazole	34 ± 14	131 ± 25
Diltiazem	45 ± 16	60 ± 3
Testosterone	60 ± 18	40 ± 3
Verapamil	256 ± 100	114 ± 11

↵6-a Determined fromV_max/K_m. Mean ± S.D.