Inhibition of NAPQI Formation by Quinidine in Human Liver Microsomes
| Liver ID | Velocity | Inhibition | |
|---|---|---|---|
| −Quinidine | +Quinidine | ||
| pmol/mg protein/min | % | ||
| 1 | 26.1 | 22.5 | 13.8 |
| 2 | 91.4 | 80.5 | 11.9 |
| 3 | 86.6 | 76.1 | 12.1 |
| 4 | 79.4 | 71.6 | 9.8 |
| 5 | 59.4 | 56.5 | 4.9 |
| 6 | 28.1 | 21.8 | 22.4 |
| 7 | 140.9 | 117.8 | 16.4 |
| 8 | 35.2 | 30.2 | 14.2 |
| 9 | 57.5 | 54.9 | 4.5 |
| 10 | 24.1 | 20.2 | 16.2 |
The mean values of duplicate experiments are reported, and the duplicate values did not vary by more than 10%.