Table 1

Pharmacokinetic parameters of LC, ALC, and PLC in the isolated perfused rat liver

ParameterLC (50 μM)ALC (15 μM)PLC (0.45 μM)
CLH (ml/min)0.66  ± 0.441.32  ± 0.301-a 3.36  ± 0.111-a 1-b
EH 0.022  ± 0.0150.044  ± 0.0091-a 0.115  ± 0.0061-a 1-b
Half-life (min)281  ± 18298  ± 111-a 31  ± 31-a 1-b
f bile(%)0.18  ± 0.060.12  ± 0.011-a 0.27  ± 0.091-a 1-b
f tissue (%)11.6  ± 2.222.7  ± 5.61-a 35.8  ± 5.21-a 1-b

Values are expressed as mean ± S.D. of four separate experiments.

  • ↵1-a  Significantly different (P < .05) than the corresponding parameter for LC.

  • ↵1-b  Significantly different (P < .05) than the corresponding parameter for ALC.