Deuteration of clopidogrel at 37°C in different solvents, as monitored by 1H NMR
| Solvents | kdeut × 10−2 |
|---|---|
| day−1 | |
| D2O, pD 1.7 | 0.30 ± 0.02 |
| d 6-DMSO/D2O (2:1) | 0.62 ± 0.03 |
| d 3-acetonitrile/D2O (1:1) | 1.59 ± 0.03 |
| d 6-DMSO/phosphate buffer, pD 7.4, 0.2 M (2:1) | 2.07 ± 0.09 |
Values are means (±standard deviation) of triplicate determinations.
kdeut, rate constant of deuteration.