In vitro inhibition by JTH-601, JTH-601-G1, and JTH-601-S1 of specific [3H]tamsulosin binding in rat tissues
| Tissues | Ki (nM) | ||
|---|---|---|---|
| JTH-601 | JTH-601-G1 | JTH-601-S1 | |
| Prostate | 2.90 ± 0.23 | 8.03 ± 2.14 | 10.8 ± 2.0 |
| Submaxillary gland | 4.04 ± 0.43 | 17.7 ± 1.5 | 25.8 ± 3.07 |
| Spleen | 5.67 ± 0.65 | 27.2 ± 6.7 | 14.0 ± 2.9 |
The competitive inhibition by JTH-601 and its metabolites of specific [3H]tamsulosin binding was examined in rat tissues in vitro. Each value represents mean ± S.E. of three to four rats.