In vivo inhibition by JTH-601, JTH-601-G1, and JTH-601-S1 of specific [3H]tamsulosin binding in rat tissues
| Tissues | ID50 (nmol/kg) | ||
|---|---|---|---|
| JTH-601 | JTH-601-G1 | JTH-601-S1 | |
| Prostate | 812 ± 228 | 388 ± 131 | 2122 ± 911 |
| Aorta | 896 ± 387 | 311 ± 81 | 1127 ± 544 |
| Submaxillary gland | 614 ± 187 | 319 ± 109 | 1971 ± 987 |
| Spleen | 387 ± 148 | 141 ± 49 | 255 ± 92 |
JTH-601 (6.5–2176 nmol/kg), JTH-601-G1 (168–1678 nmol/kg), and JTH-601-S1 (204–2038 nmol/kg) were injected together with [3H]tamsulosin (555 kBq, 1.3 nmol/kg) into the femoral vein of rats, and 10 min later, specific [3H]tamsulosin binding was measured. Each value represents mean ± S.D. of 24 to 30 rats.