Table 1

Serum VPA and VG concentrations, and apparent VPA clearance, after various continuous infusion rates of VPA (n = 1 rat per infusion rate), with and without PRB treatment

Continuous VPA Infusion RateSerum VPA Concentration at 60 minSerum VG Concentration at 60 minApparent Clearance1-a
mg/h μg/ml ml/min
Control1-b
  3.187.462.657.10
  7.3617.418.77.05
 14.761.151.64.01
 21.013249.02.65
 44.13011102.44
 72.05342722.25
 98.09951511.26
PRB1-b 1-c
  2.289.013.374.22
  4.2036.501.92
  9.0057.285.72.62
 13.21281231.72
 26.04011411.08
 49.085190.80.960

  • ↵1-a  Clearance = VPA infusion rate/serum VPA concentration at 60 min.

  • ↵1-b  Apparent clearance was statistically different across infusion rates, P < .05.

  • ↵1-c  Apparent clearance was statistically different from control, P < .05.