Distribution of VPA in hepatic subcellular fractions relative to whole liver homogenate after infusion of VPA to steady state
| Subcellular Fraction2-a | Vehicle (n = 7)2-b | Probenecid (n = 6)2-b |
|---|---|---|
| Nuclear | 0.523 ± 0.110 | 0.621 ± 0.137 |
| Mitochondrial | 0.212 ± 0.052 | 0.175 ± 0.032 |
| Lysosomal | 0.211 ± 0.092 | 0.210 ± 0.042 |
| Microsomal | 0.248 ± 0.178 | 0.194 ± 0.070 |
| Cytosolic2-c | 2.82 ± 0.90 | 3.37 ± 0.77 |
↵2-a Data are expressed as mean ± S.D.; concentrations of VPA in each fraction were normalized for the respective concentration in whole liver homogenate.
↵2-b Significantly different across fractions; P < .001.
↵2-c Significantly different from all other subcellular fractions (Tukey's Studentized range test);P < .05.