Concentration-dependent PRB inhibition of VPA glucuronidation
| PRB | Vmax | Km3-a |
|---|---|---|
| μg/ml | μg/min/mg of protein | μg/ml |
| 0 | 0.80 ± 0.06 | 173 ± 29 |
| 7.14 | 0.98 ± 0.09 | 273 ± 59 |
| 14.3 | 1.09 ± 0.13 | 371 ± 91 |
| 143 | 0.75 ± 0.12 | 342 ± 87 |
| 714 | 0.88 ± 0.15 | 461 ± 124 |
| 2850 | 0.76 ± 0.37 | 584 ± 278 |
Data are expressed as mean ± S.D. (n = 3) based on five VPA concentrations (7.2–721 μg/ml) per preparaton.
↵3-a Significantly different across PRB treatment; P = .0194, one-way ANOVA.