Compound | Absolute Mean IC50Values | Overall | Range | Relative Mean IC50 Values | ||||||
---|---|---|---|---|---|---|---|---|---|---|
BzRes | BQ | DBF | BFC | BzRes | BQ | DBF | BFC | |||
Astemizole | 145.0 | 2.2 | 3.1 | 1.2 | 37.9 | 120.8 | 3.83 | 0.06 | 0.08 | 0.03 |
Carbamazepine | Activation | 479 | 90 | 175 | 248 | 5.3 | 1.93 | 0.36 | 0.71 | |
Cisapride | 0.424 | 0.022 | 0.938 | 0.022 | 0.352 | 42.1 | 1.21 | 0.06 | 2.67 | 0.06 |
Clotrimazole | 0.019 | 0.013 | 0.005 | 0.002 | 0.010 | 7.9 | 1.95 | 1.29 | 0.52 | 0.25 |
Cyclosporin | 1.2 | 235.0 | 3.3 | 3.1 | 60.7 | 195.0 | 0.02 | 3.87 | 0.05 | 0.05 |
Digitoxin | >20 | >20 | >20 | >20 | ||||||
Erythromycin | 1.8 | 74.0 | 26.5 | 4.6 | 26.7 | 41.2 | 0.07 | 2.77 | 0.99 | 0.17 |
Ethynylestradiol | 6.4 | 3.8 | 3.3 | 1.4 | 3.7 | 4.5 | 1.72 | 1.01 | 0.89 | 0.38 |
Haloperidol | Activation | 202 | 50 | 52 | 101 | 4.0 | 1.99 | 0.49 | 0.51 | |
Itraconazole | 0.176 | 0.350 | 0.038 | 0.034 | 0.150 | 10.2 | 1.18 | 2.34 | 0.25 | 0.23 |
Ketoconazole | 0.034 | 0.072 | 0.002 | 0.005 | 0.028 | 45.9 | 1.20 | 2.56 | 0.06 | 0.18 |
Mibefradil | 0.021 | 0.066 | 0.055 | 0.005 | 0.037 | 12.4 | 0.56 | 1.81 | 1.49 | 0.15 |
Miconazole | 0.175 | 0.302 | 0.058 | 0.057 | 0.148 | 5.3 | 1.18 | 2.04 | 0.39 | 0.38 |
Midazolam | 59.8 | 3.6 | 1.7 | 1.3 | 16.6 | 47.7 | 3.61 | 0.22 | 0.10 | 0.08 |
Naphthoflavone | Activation | Activation | 147 | Activation | 147 | |||||
Nicardipine | 0.044 | 0.273 | 0.225 | 0.051 | 0.148 | 6.2 | 0.30 | 1.84 | 1.52 | 0.34 |
Nifedipine | 68.8 | 16.5 | 4.1 | 8.4 | 24.4 | 16.7 | 2.81 | 0.68 | 0.17 | 0.34 |
Nimodipine | 0.750 | 1.370 | 0.735 | 0.370 | 0.806 | 3.7 | 0.93 | 1.70 | 0.91 | 0.46 |
Progesterone | Activation | >200 | 11.5 | Activation | 11.5 | |||||
Propofol | >100 | 106 | 97 | 51 | 85 | 2.1 | 1.25 | 1.14 | 0.61 | |
Quercetin | >50 | >50 | >50 | >50 | ||||||
Quinidine | 134 | 125 | 105 | 34 | 99 | 4.0 | 1.34 | 1.26 | 1.06 | 0.34 |
Tamoxifen | Activation | >1000 | >1000 | >1000 | ||||||
Terfenadine | Activation | 6.33 | 2.13 | 0.99 | 3.15 | 6.4 | 2.01 | 0.68 | 0.31 | |
Testosterone | Activation | >1000 | 32 | Activation | 32 | |||||
Troleandomycin | 0.29 | 6.10 | 1.92 | 0.41 | 2.18 | 20.9 | 0.13 | 2.80 | 0.88 | 0.19 |
Verapamil | 0.40 | 8.40 | 4.23 | 0.36 | 3.35 | 11.8 | 0.12 | 2.51 | 1.26 | 0.11 |
Mean | 29.2 | 1.30 | 1.71 | 0.76 | 0.28 |
The relative mean IC50 value is defined as the absolute mean IC50 value divided by the overall mean IC50 value.