Table 2

Absolute and relative mean IC₅₀ values (μM)

Compound	Absolute Mean IC₅₀Values		Overall	Range	Relative Mean IC₅₀ Values
Compound	BzRes	BQ	Overall	Range	DBF	BFC	BzRes	BQ	DBF	BFC
Astemizole	145.0	2.2	3.1	1.2	37.9	120.8	3.83	0.06	0.08	0.03
Carbamazepine	Activation	479	90	175	248	5.3		1.93	0.36	0.71
Cisapride	0.424	0.022	0.938	0.022	0.352	42.1	1.21	0.06	2.67	0.06
Clotrimazole	0.019	0.013	0.005	0.002	0.010	7.9	1.95	1.29	0.52	0.25
Cyclosporin	1.2	235.0	3.3	3.1	60.7	195.0	0.02	3.87	0.05	0.05
Digitoxin	>20	>20	>20	>20
Erythromycin	1.8	74.0	26.5	4.6	26.7	41.2	0.07	2.77	0.99	0.17
Ethynylestradiol	6.4	3.8	3.3	1.4	3.7	4.5	1.72	1.01	0.89	0.38
Haloperidol	Activation	202	50	52	101	4.0		1.99	0.49	0.51
Itraconazole	0.176	0.350	0.038	0.034	0.150	10.2	1.18	2.34	0.25	0.23
Ketoconazole	0.034	0.072	0.002	0.005	0.028	45.9	1.20	2.56	0.06	0.18
Mibefradil	0.021	0.066	0.055	0.005	0.037	12.4	0.56	1.81	1.49	0.15
Miconazole	0.175	0.302	0.058	0.057	0.148	5.3	1.18	2.04	0.39	0.38
Midazolam	59.8	3.6	1.7	1.3	16.6	47.7	3.61	0.22	0.10	0.08
Naphthoflavone	Activation	Activation	147	Activation	147
Nicardipine	0.044	0.273	0.225	0.051	0.148	6.2	0.30	1.84	1.52	0.34
Nifedipine	68.8	16.5	4.1	8.4	24.4	16.7	2.81	0.68	0.17	0.34
Nimodipine	0.750	1.370	0.735	0.370	0.806	3.7	0.93	1.70	0.91	0.46
Progesterone	Activation	>200	11.5	Activation	11.5
Propofol	>100	106	97	51	85	2.1		1.25	1.14	0.61
Quercetin	>50	>50	>50	>50
Quinidine	134	125	105	34	99	4.0	1.34	1.26	1.06	0.34
Tamoxifen	Activation	>1000	>1000	>1000
Terfenadine	Activation	6.33	2.13	0.99	3.15	6.4		2.01	0.68	0.31
Testosterone	Activation	>1000	32	Activation	32
Troleandomycin	0.29	6.10	1.92	0.41	2.18	20.9	0.13	2.80	0.88	0.19
Verapamil	0.40	8.40	4.23	0.36	3.35	11.8	0.12	2.51	1.26	0.11
Mean						29.2	1.30	1.71	0.76	0.28

The relative mean IC₅₀ value is defined as the absolute mean IC₅₀ value divided by the overall mean IC₅₀ value.