Vmax | Km | S | |||||
---|---|---|---|---|---|---|---|
Sulfone | 6-Hydroxy | Pyridone | Sulfone | 6-Hydroxy | Pyridone | Sulfone | |
Human liver, S-form | |||||||
HL 100 | 1.69 (3.6) | 0.45 (3.3) | 0.09 (4.1) | 232 (0.08) | 50.0 (11.9) | 27.4 (16.8) | 1.36 (0.07) |
HL 105 | 0.93 (5.8) | 0.30 (3.2) | 0.10 (5.8) | 413 (11.4) | 14.9 (16.0) | 13.5 (29.9) | 1.24 (5.7) |
HL 106 | 0.51 (4.7) | 0.14 (3.2) | 0.03 (12.6) | 462 (9.1) | 42.8 (13.1) | 175 (37.2) | 1.18 (4.0) |
Mean | 1.04 | 0.30 | 0.08 | 369 | 35.9 | 72.0 | 1.26 |
S.D. | 0.60 | 0.16 | 0.03 | 121 | 18.5 | 89.5 | 0.09 |
Human liver, R-form | |||||||
HL 100 | 0.54 (13.3) | 0.36 (5.8) | 0.10 (2.6) | 692 (27.4) | 55.1 (21.9) | 33.1 (11.4) | 1.00 |
HL 105 | 0.34 (16.5) | 0.63 (6.7) | 0.26 (8.9) | 514 (28.6) | 103 (20.8) | 95.1 (61.4) | 1.43 (14.7) |
HL 106 | 0.26 (53.8) | 0.29 (13.2) | 0.11 (10.4) | 1000 (91.5) | 430 (27.4) | 263 (23.6) | 1.08 (21.3) |
Mean | 0.38 | 0.43 | 0.16 | 735 | 196 | 130 | 1.17 |
S.D. | 0.14 | 0.18 | 0.09 | 246 | 204 | 119 | 0.23 |
Km expressed as micromoles per liter andVmax as nanomoles per minute per milligram protein.
S, sigmoidicity factor.