Comparison of renal clearance of unchanged drug in male and female rats after gonadectomy treatment and nontreatment
| Sex | Treatment | Renal Clearance of Unchanged Drug |
|---|---|---|
| ml/min/kg | ||
| Male | Nontreatment | 0.009 ± 0.002 |
| Male | Gonadectomy | 0.158 ± 0.024 |
| Female | Nontreatment | 0.193 ± 0.030 |
| Female | Gonadectomy | 0.272 ± 0.055 |
Significant difference with Tukey-Kramer multiple comparison test, * P < .05, ** P < .01 (n = 4, means ± S.E.).