Table 1

Linear correlation coefficients between pimobendan O-demethylase activity and specific activities for various CYP isoforms

CYPSpecific ReactionCorrelation with PimobendanO-Demethylase Activity (r2)
CYP1A2PhenacetinO-deethylation0.715**
CYP2A6Coumarin 7-hydroxylation0.199
CYP2C9Tolbutamide hydroxylation0.744**
CYP2C19 S-Mephenytoin 4′-hydroxylation0.210
CYP2D6Desipramine 2-hydroxylation0.380*
CYP2E14-Nitrophenol hydroxylation0.095
CYP3A4ErythromycinN-demethylation0.760**

  • n = 16, * P < .05, and ** P < .001.